Lispro Insulin: A Fast-Acting Solution for Diabetes Management

Lispro Insulin: A Fast-Acting Solution for Diabetes Management

If you have diabetes, you know how important it is to manage your blood sugar levels. Insulin is a hormone that regulates glucose in the bloodstream, and for those with diabetes, insulin therapy is often necessary. One type of insulin that is commonly prescribed is lispro insulin. In this article, we'll take a closer look at lispro insulin, its mechanism of action, side effects, and how it compares to other types of insulin.
Lispro Insulin
Lispro Insulin

What is Lispro Insulin?

Lispro insulin is a rapid-acting insulin analog that is used to treat both type 1 and type 2 diabetes. It works by mimicking the natural insulin produced by the body, helping to regulate blood sugar levels after meals. Unlike regular insulin, which can take up to an hour to start working, lispro insulin begins working within 10-15 minutes of injection.

How Does Lispro Insulin Work?

Lispro insulin has the same amino acid sequence as regular insulin, but the order of the amino acids is slightly different. This difference allows lispro insulin to be absorbed more quickly than regular insulin, which is why it is considered a rapid-acting insulin. When lispro insulin is injected, it begins working within 10-15 minutes, reaching its peak effectiveness within 30-90 minutes. This rapid onset makes it a good choice for people who need insulin to cover their meals. It is typically taken just before a meal or within 15 minutes after starting a meal.

Lispro Insulin vs. Other Types of Insulin

There are several other types of insulin available, including regular insulin, long-acting insulin, and rapid-acting insulin analogs like aspart and glulisine. Compared to regular insulin, lispro insulin has a faster onset and a shorter duration of action.

Long-acting insulin, such as Lantus, provides a slow, steady release of insulin over a 24-hour period, while lispro insulin is designed to work quickly and only last for a few hours. Another rapid-acting insulin analog that is often compared to lispro insulin is Humalog.

While both Humalog and lispro insulin are rapid-acting, they have slightly different amino acid sequences, which can affect their absorption and effectiveness. In general, the two insulins are considered interchangeable, but some people may find that one works better for them than the other.
You might like: Insulin Resistance Diet: What to Eat and What to Avoid

Lispro Insulin Side Effects

As with any medication, lispro insulin can cause side effects. The most common side effect is hypoglycemia, or low blood sugar. Symptoms of hypoglycemia include sweating, dizziness, shakiness, and confusion. Other potential side effects include injection site reactions, such as redness or swelling, and weight gain.
also read: Diabetes Insipidus: Symptoms, Treatment, and Causes

Conclusion

Lispro insulin is a fast-acting insulin analog that can help people with diabetes manage their blood sugar levels. It is typically taken just before or after meals and begins working within 10-15 minutes of injection. While it may cause side effects like hypoglycemia, many people find that it is an effective treatment for their diabetes. If you are interested in trying lispro insulin, talk to your doctor to see if it is right for you.

References

  1. Lispro (marketed as Humalog) Information. U.S. Food and Drug Administration. https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/lispro-marketed-humalog-information. Published 2018. Accessed April 17, 2023.
  2. Lispro: MedlinePlus Drug Information. MedlinePlus. https://medlineplus.gov/druginfo/meds/a601211.html. Accessed April 17, 2023.
  3. Insulin lispro. LiverTox. National Institutes of Health. https://livertox.nlm.nih.gov/InsulinLispro.htm. Published 2021. Accessed April 17, 2023.
  4. Humalog [package insert]. Indianapolis, IN: Eli Lilly and Company; 2019. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/020563s162lbl.pdf. Accessed April 17, 2023.
  5. Heinemann L. Insulin lispro: a critical review of its use in the management of diabetes mellitus. Treat Endocrinol. 2004;3(1):23-40. doi: 10.2165/00024677-200403010-00003
  6. Garg S, Rosenstock J, Ways K. Optimized Basal-Bolus Insulin Regimens in Type 1 Diabetes: Insulin Lispro versus Regular Human Insulin in Combination with Basal Insulin Glargine. Endocr Pract. 2010;16(2):266-275. doi: 10.4158/EP09158.OR
  7. Insulin Lispro - DrugBank. DrugBank. https://www.drugbank.ca/drugs/DB00046. Published 2021. Accessed April 17, 2023.
  8. Chan AK, Jensen K, Petrie D, et al. Comparison of Insulin Glulisine versus Insulin Lispro and Regular Human Insulin in Combination with Metformin in Type 2 Diabetes Mellitus: A Randomized Open-Label Study. Clin Ther. 2008;30(3):495-504. doi: 10.1016/j.clinthera.2008.03.003
  9. Højbjerre L, Alibegovic AC, Sonne MP, et al. Impact of insulin lispro on glucose turnover and lipolysis in type 1 diabetes. Diabetes Obes Metab. 2014;16(4):334-341. doi: 10.1111/dom.12228
  10. Misra S, Oliver NS. Utility of insulin lispro in the management of diabetes mellitus. Diabetes Metab Syndr Obes. 2011;4:251-264. doi: 10.2147/DMSO.S11210

Mohamed Fayez

Mohamed is an Egyptian programmer, he loves science and programming. he is working as a freelancer programmer and a blockchain Developer/Investor.

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